New estrogenic antagonists bearing dicarba-closo-dodecaborane as a hydrophobic pharmacophore.
نویسندگان
چکیده
We have designed and synthesized estrogen antagonists bearing dicarba-closo-dodecaborane (carborane) as a hydrophobic pharmacophore based on the structure of 1-(4-hydroxyphenyl)-1,12-dicarba-closo-dodecaborane, a potent estrogen agonist that we reported previously. Compounds with a long alkyl chain bearing an amide moiety on the carborane skeleton (6, 7) showed estrogen antagonistic activity in a luciferase reporter gene assay using COS-1 cells transfected with a rat ER alpha-expression plasmid and as an appropriate reporter plasmid.
منابع مشابه
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عنوان ژورنال:
- Chemical & pharmaceutical bulletin
دوره 48 2 شماره
صفحات -
تاریخ انتشار 1999